Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

E Scarr; M Udawela; B Dean

Journal article

Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia

E Scarr, M Udawela, B Dean

Npj Schizophrenia | NATURE PUBLISHING GROUP | Published : 2018

DOI: 10.1038/s41537-018-0044-x

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Abstract

Schizophrenia (Sz) probably occurs after genetically susceptible individuals encounter a deleterious environmental factor that triggers epigenetic mechanisms to change CNS gene expression. To determine if omnibus changes in CNS gene expression are present in Sz, we compared mRNA levels in the frontal pole (Brodmann's area (BA) 10), the dorsolateral prefrontal cortex (BA 9) and cingulate cortex (BA 33) from 15 subjects with Sz and 15 controls using the Affymetrix™ Human Exon 1.0 ST Array. Differences in mRNA levels (±≥20%; p < 0.01) were identified (JMP Genomics 5.1) and used to predict pathways and gene x gene interactions that would be affected by the changes in gene expression using Ingenu..

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University of Melbourne Researchers

Brian Dean Author Florey Department of Neuroscience and Mental Health

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Awarded by National Science Foundation

Funding Acknowledgements

The authors gratefully acknowledge Geoff Pavey for his technical assistance and curation of the human brain tissue. Tissue was sourced from the Victorian Brain Bank, supported by the Mental Health Research Institute, The Alfred, Victorian Forensic Institute of Medicine, The University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services. This project was supported by the National Health and Medical Research Council (Australia; project grant 566967, Fellowship (BD) APP1002240), the Australian Research Council (Fellowship (ES) FT100100689) and the Victorian Government's Operational Infrastructure Support Programme.